Jack Halsey takes his wife, their adult kids, and a friend for a dream vacation in Kenya. But as they venture off alone into a wilderness park, their safari van is flipped over by an angry rhino, leaving them injured and desperate. Then, as two of them go in search of rescue, a bloody, vicious encounter with a leopard and a clan of hyenas incites a desperate fight for survival.

In 1959, psychiatrist Dr. Alan Stone arrives at a mental hospital in Ypsilanti, Michigan armed with the radical belief that schizophrenic patients should be treated with empathy and understanding. As his first study, he takes on the particularly challenging case of three men: Joseph, Leon, and Clyde, each of whom believes they are Jesus Christ. Dr. Stone begins a risky, unprecedented experiment that will push the boundaries of psychiatric medicine...

After visiting a fortune teller, Edmond realizes his life is not the one he desires. He decides to flee his previous existence and pursue a new life. Edmond meets a man in a bar who gives his advice that launches a series of mishaps that ultimately guide him through the search for his humanity.